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B Lymphocyte Development

Stages of B Cell Development –defined by the sequential rearrangement and expression of heavy- and light-chain immunoglobulin genes

Antigen Independent Stage

Important Terms relating to the Antigen Independent Stage of B-Cell Development:

Antigen Dependent Stage

B-1 B Cells vs. B-2 B Cells

Property

B-1 B cells

Conventional B-2 B cells

When 1st produced

Fetus

After birth

Mode of renewal

Self-renewing

Replaced from bone marrow

Production of immunoglobulin

High

Low

Specificity

Degenerate

Precise

Isotypes secreted

IgM >> IgG

IgG > IgM

Somatic hypermutation

Low-none

High

Response to carbohydrate antigen

Yes

Maybe

Response to protein antigen

Maybe

Yes

B-Cell Diseases