Microbial Virulence

Success for an extracellular pathogen – measured in terms of passing genetic info to progeny



Host Defense and Virulence Factors – the host comes up with ways to kill the bacteria and the bacteria use Virulence Factors to overcome these efforts. The number and effectiveness of such tricks define the Relative Virulence of the organism for its host.

Bacterial Exotoxins – made by bug and secreted into extracellular environment; Generic mechanism: Two component system. First component absorbs to surface of target cell and facilitates transfer of second component – which exerts the toxic effect

Pyrogenic Exotoxins

Bacterial Endotoxins – intrinsic part of bug which is released after its death