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Principles of Antibiotic Usage

Bactericidal vs. Bacteriostatic

Chemoprophylaxis administration in the absence of infection or contamination


Causative Organism

Prophylactic Antimicrobial

Acute rheumatic fever

Group A streptococci

Penicillin, erythromycin

Meningococcal infection

Neisseria meningitidis

Sulfonamides, minocycline,

Infective endocarditis
Oral cavity, instrumentation

"viridans" streptococcus

Penicillin, cephalosporin

Urogenital or GI instrumentation


Penicillin, or vancomycin plus gentamicin

Tuberculin reactors*

Mycobacterium tuberculosis


Ophthalmia neonatorum

Neisseria gonorrhoeae

Silver nitrate, penicillin, erythromycin