Globin Synthesis and Abnormal Hemoglobin

Overview – Hemoglobin (Hgb) tetrameric protein comprised of 2 a-like globin chains and 2 b-like globin chains.

Globin gene organization and developmental expression

Regulation of globin gene expresion and the thalassemias

RNA Processing

Translation – initiation, elongation, termination

Protein stability/multimer formation

Abnormal Hemoglobin – Over 500 structural Hb variants have been described. More b than a chain mutations.

Clinically significant hemoglobinopathies