Hodgkin's Disease

Epidemiology

Rye Classification of Hodgkin's Disease – 4 subtypes

Subgroup

Histologic Features

Frequency

Prognosis

Lymphocyte Predominant

Abundant lymphocytes ± histiocytes

occasional R-S cell

5%

Excellent

Nodular Sclerosis

Nodules of lymphoid infiltrates separated by bands of fibrous tissue. Lacunar cells (R-S variant)

78%

Good

Mixed Cellularity

Pleomorphic infiltrate of lymphocytes, plasma cells, histiocytes, eosinophils with numerous R-S cells

17%

Intermediate

Lymphocyte Depleted

Paucity of lymphocytes with numerous R-S cells

1%

Poor

Etiology – unknown

Clinical Presentation

Diagnosis – Requires tissue (usually a lymph node)

Staging

Treatment – All patients are potentially curable