Make your own free website on Tripod.com

RBC Structure and Function

Erythroid marrow

Red cell metabolism

Hemoglobin function – Cooperative binding of O2 (ie when binds one O2 binding of further O2 becomes easier).

RBC life cycle – RBCs are subjected to much stress, live for about 120 days, spleen removes dying RBCs.

Oxygen Supply

Red Cell Production and Destruction

 

Production
Reticulocyte index

Marrow E G

Destruction
Bilirubin

NORMAL (basal)
ANEMIA

1.0

1:3

Normal

Hemolytic

>3.0

>1:1

Increased

Hypoproliferative

<2.0

<1:3

Decreased

Ineffective erythropoiesis

<2.0

>1:1

Increased

Normal Values and Pathological Changes

Conclusions