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Red Cell Antigens and Antibodies

Introduction

Blood Group Systems

Genetic Basis of Blood Group Antigens (Simplistically!)

Antigens have variable Structure, which affects their reactivity serologically

Blood Group Antibodies

Antiglobulin Reaction: Coombs' Test (this is how many Groups were discovered: Rh, Kell, Duffy, Kidd and Xga)

  

Mechanisms of red cell destruction by antibody in vivo