Progression of Chronic Renal Disease
Nephron adaptation to injury:
Change in function |
Beneficial Effect |
Adverse effect |
Ý GFR |
Ý solute excretion |
Accelerates glomerular injury |
Ý fractional excretion of Na |
Prevents Ý ECF |
Slow adaptation to Na restriction |
Ý PTH |
ß phosphate retention |
Bone disease |
Ý NH3 secretion |
ß systemic acidosis |
Ý progression of tubulointerstitial disease |
Mechanisms of injury initiation:
Mechanisms of renal disease progression
End stage renal Disease
Management of renal disease progression: