Tubulointerstitial Disease
Site of injury |
Example of Acute disease |
Example of chronic disease |
Associated tubular dysfunction |
Cortex/proximal tubule |
myeloma, antibiotics |
heavy metals, myeloma, SLE |
proximal tubular wasting of aa's, HCO3, glu, PO4, Na, urate |
cortex/distal |
NSAIDS, antibiotics |
obstruction, SLE, amyloid, sickle cell |
decreased K+ secretion, decreased Na+ reabsorbtion |
medulla |
analgesics, sickle cell, myeloma, |
analgesics, metabolic disorders, amyloid, sickle cell |
impaired urinary concentrating ability |
papilla |
infections, sickle cell |
analgesics, infection, obstruction |
impaired urinary concentrating ability |
Mechanisms of injury
:Clinical Differentiation of upper versus lower tract disease
Interstitial Nephritis (IN)
Cystic Diseases