Osteoarthritis

Osteoarthritis most common type of joint disease

Pathogenesis

Histology

Clinical Manifestations

Diagnosis and Treatment

 

Osteoarthritis

Rheumatoid arthritis

Where it originates

Articular Cartilage

Synovium

Joints

  1. weight bearing (hips, knees, back)
  2. PIP and DIP (also MP and TP)
  1. hands, feet, wrists, elbow

Histology

  • chondrocyte clustering
  • metachromasia
  • fibrillation (flaking)
  • subchondral thickening
  • subchondral cysts
  • synovitis leading to edema, vascular proliferation, inflammatory infiltrates, Pannus
  •