Paraneoplastic Disorders

• Limbic encephalitis – associated with small cell lung cancer
• perivascular mononuclear infiltrate without viral inclusions
• Affects medial temporal lobe, cingulate gyrus, insula
• Hyperintensity on T2
• M>F
• Anti-Yo – cerebellar degeneration, ovary/breast cancer
• Anti-Hu – sensory neuropathy, oat cell cancer
• Anti-Ri – opsoclonus, breast cancer
• Stiffman Syndrome – involuntary spasms/rigidity; 60% have antibodies to glutamic acid decarboxylase