Hodgkin's Disease
Epidemiology
Rye Classification of Hodgkin's Disease
4 subtypes
Subgroup |
Histologic Features |
Frequency |
Prognosis |
Lymphocyte Predominant |
Abundant lymphocytes ± histiocytes occasional R-S cell |
5% |
Excellent |
Nodular Sclerosis |
Nodules of lymphoid infiltrates separated by bands of fibrous tissue. Lacunar cells (R-S variant) |
78% |
Good |
Mixed Cellularity |
Pleomorphic infiltrate of lymphocytes, plasma cells, histiocytes, eosinophils with numerous R-S cells |
17% |
Intermediate |
Lymphocyte Depleted |
Paucity of lymphocytes with numerous R-S cells |
1% |
Poor |
Etiology
unknownClinical Presentation
Diagnosis
Requires tissue (usually a lymph node)Staging
Treatment
All patients are potentially curable