RBC Structure and Function
Erythroid marrow
Red cell metabolism
Hemoglobin function
– Cooperative binding of O2 (ie when binds one O2 binding of further O2 becomes easier).RBC life cycle
– RBCs are subjected to much stress, live for about 120 days, spleen removes dying RBCs.Oxygen Supply
Red Cell Production and Destruction
|
Production |
Marrow E G |
Destruction |
NORMAL (basal) |
1.0 |
1:3 |
Normal |
Hemolytic |
>3.0 |
>1:1 |
Increased |
Hypoproliferative |
<2.0 |
<1:3 |
Decreased |
Ineffective erythropoiesis |
<2.0 |
>1:1 |
Increased |
Conclusions