Chronic Liver Injury

Causes of Chronic Liver Injury – Three Mechanisms

Results of Chronic Liver Injury – usually cirrhosis

Grading Schemes

Histopathological Features


Portal Hypertension – when WHVP exceeds IVC pressure by more than 4 mmHg

Acites – most common complication of cirrhosis, Ascites does not develop without portal hypertension

Hepatic Encephalopathy

Hepatorenal Syndrome – unexplained renal failure in patients with severe liver disease